Panama is a village in Chautauqua County, New York, United States. The population was 479 at the 2010 census. Panama is in the northwest part of the town of Harmony, at the junction of State Route 474 (Main Street) and County Route 33.
According to the United States Census Bureau, the village has a total area of 2.2 square miles (5.7 km), of which 0.008 square miles (0.02 km), or 0.27%, is water.
As of the census of 2000, there were 491 people, 191 households, and 135 families residing in the village. The population density was 226.4 people per square mile (87.4/km²). There were 208 housing units at an average density of 95.9 per square mile (37.0/km²). The racial makeup of the village was 96.74% White, 1.02% African American, 0.20% Native American, 0.20% Asian, 0.41% from other races, and 1.43% from two or more races. Hispanic or Latino of any race were 0.61% of the population.
There were 191 households out of which 31.9% had children under the age of 18 living with them, 61.3% were married couples living together, 7.9% had a female householder with no husband present, and 29.3% were non-families. 22.5% of all households were made up of individuals and 14.7% had someone living alone who was 65 years of age or older. The average household size was 2.57 and the average family size was 3.07.
In the village, the population was spread out with 26.7% under the age of 18, 5.9% from 18 to 24, 25.7% from 25 to 44, 25.5% from 45 to 64, and 16.3% who were 65 years of age or older. The median age was 40 years. For every 100 females, there were 97.2 males. For every 100 females age 18 and over, there were 88.5 males.
The median income for a household in the village was $31,250, and the median income for a family was $38,125. Males had a median income of $31,944 versus $20,833 for females. The per capita income for the village was $16,410. About 9.6% of families and 11.7% of the population were below the poverty line, including 18.0% of those under age 18 and 7.0% of those age 65 or over.